Introduction + Classification + Pharmacological Action + Regulation of Release and Drawback of Glucocorticoids Hormone


Introduction

Glucocorticoid hormone is a steroidal hormone. It releases from zona fasciculata layer of adrenal cortex of the adrenal gland. Glucocorticoid hormone is steroidal in nature. A release of glucocorticoid hormone is controlled by the hypothalamus.

Classification

Glucocorticoids are classified as following…

1- Natural Glucocorticoid

There are following natural glucocorticoids.

  • Cortisol
  • Cortisone
  • Corticosterone

2- Synthetic Glucocorticoid

There are following synthetic glucocorticoids.

  • Prednisone
  • Prednisolone
  • Triamcinolone
  • Dexamethasone
  • Paramethasone

Note: Synthetic glucocorticoids having more anti-inflametory activity the anabolic activity of natural glucocorticoids.

Introduction + Classification + Pharmacological Action + Regulation of Release and Drawback of Glucocorticoids Hormone

Pharmacological Action

Glucocorticoids have a following pharmacological action.

1- Carbohydrate Metabolism:
Glucocorticoid hormone increases the gluconeogenesis (formation of glucose) process.

2- Fat Metabolism:
Glucocorticoid hormone helps to increase lypogenesis (formation of lipids) process, proliferation and distribution of fat in the body.

3- Glucocorticoid is also involved in the protein synthesis process.

4- It helps to enhance the production of ATP.

5- Glucocorticoids increase the osteoporosis (increase Ca+ level in skeleton muscle and bone.)

6- It is a anti-inflammatory in nature and also helpful for the balance of electrolyte & water balance.

Regulation of Release/Mode of Action

Introduction + Classification + Pharmacological Action + Regulation of Release and Drawback of Glucocorticoids Hormone

Drawback

Hyposecreation- Hyposecreation of glucocorticoids cause Addission diseases and they are the followings.

  1. Loss of body weight
  2. Hypotension
  3. GIT disorder
  4. Skin pigmentation

Hypersecreation- Hypersecreation of cause cushing syndrome.

Cushing syndrome- increases the deposition of fat on the face, neck, abdominal & hip region.


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Ankita Rai
Hey, I'm graduated in Pharmacy and working with a top reputed company as quality control and analysis. I love to share my ideas, and knowledge with everyone by writing articles on the latest pharmacy trends and thanks to Websparrow team to provide me a platform.